Gdf15 gene-targeted mice also demonstrated a pronounced loss in ventricular performance following only 2 weeks of pressure overload stimulation, whereas wild-type controls maintained function.

Professor Chris Lord is Deputy Head of Division and the leader of the CRUK Gene Function Team, which applies concepts such as synthetic lethality and non-oncogene addiction to provide one route to ...

Recently, a role for PLIN2 in supporting mitochondrial function has emerged ... increase in GDF15 is the mediator of this phenomenon. Moreover, GDF15 KD caused a profound alteration of gene expression ...

The anti-GDF15 antibody can be humanized or human, and specific sequences are highlighted for optimal efficacy. Moreover, the patent also covers a method for enhancing renal function in individuals ...

Reduced KDM5B gene function affects memory formation and learning abilities in mice KDM5B gene, previously linked to intellectual disabilities, plays a crucial role in brain development Insights ...

Summary: Researchers identified a critical role for the gene KDM5B in learning and memory. Their study demonstrates that mice with reduced function of this gene exhibit significant deficits in memory ...

If cells in the lung receive gene therapy and produce functional CFTR proteins, cells in other parts of the body still would not be able to produce CFTR. Different delivery methods would be needed to ...

To determine the function of Ikaros in the Treg lineage, we generated mice with Treg-specific deletion of the Ikaros gene (Ikzf1). We find that Ikaros cooperates with Foxp3 to establish a major ...

The theory is that trauma can change the way our genes function, and those changes are then transmitted to future generations. There appears to be some evidence that this happens, but more research is ...